eukaryotic initiation factor 4e การใช้

• The VPg protein interacts with eukaryotic initiation factor 4E ( eIF4E ).
• The encoded protein also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase.
• Phosphorylation of eukaryotic initiation factor 4e ( eif-4E ) [ 4EBP ] by mTOR inhibits the capacity of 4EBP to inhibit eif-4E and slow metabolism.
• MTORC1 activates transcription and translation through its interactions with p70-S6 Kinase 1 ( S6K1 ) and 4E-BP1, the eukaryotic initiation factor 4E ( eIF4E ) binding protein 1.
• This gene encodes a member of the EIF4EBP family which derives it name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F . Co-transcription of this gene and the neighboring upstream gene ( MASK ) generates a transcript ( MASK-BP3 ) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.